Biomedical application of Indole-3-carbinol: A mini-review
نویسندگان
چکیده
منابع مشابه
Indole-3-Carbinol Monograph
Introduction Indole-3-carbinol (I3C) is a compound found in high concentrations in Brassica family vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. As a nutritional supplement, I3C has received attention in recent years as a promising preventive and treatment agent for breast and other types of cancers, and may have beneficial effect in the management of Herpes simple...
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This study explored the effects of indole-3-carbinol on the proliferation of human nasopharyngeal carcinoma, both in vitro and in vivo, and the underlying mechanisms in inducing apoptosis of CNE1 cells. Proliferation, apoptosis, malondialdehyde, superoxide dismutase, glutathione peroxidase, expressions of caspase-9, and caspase-3 in human nasopharyngeal carcinoma cells CNE1 were examined. Indol...
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متن کاملIndole-3-carbinol is a negative regulator of estrogen.
Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. Epidemiological, laboratory, animal and translational studies support the efficacy of I3C. Whereas estrogen increases the growth and survival of tumors, I3C causes growth arrest and increased apoptosis and ameliorates the ef...
متن کاملEstrogen receptor a as a target for indole-3-carbinol
A wealth of preclinical evidence supports the antitumorigenic properties of indole-3-carbinol (I3C), which is a major bioactive food component in cruciferous vegetables. However, the underlying molecular mechanism(s) accounting for these effects remain unresolved. In the present study, estrogen receptor alpha (ER-a) was identified as a potential molecular target for I3C. Treating MCF-7 cells wi...
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ژورنال
عنوان ژورنال: Phytochemistry Letters
سال: 2021
ISSN: 1874-3900
DOI: 10.1016/j.phytol.2020.09.024